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Emotional and Physical Distress Cured with New Endorphinergic Formulation




Specific biochemical imbalance in the endorphin system, the stress center of the brain and gut, underlie the emotional and physical distress experienced by millions of sufferers of a wide variety of clinical conditions. The Endorphinergic Distress Syndrome is responsible, in part, for chronic anxiety, anger, depression, cravings, and pain hypersensitivity.

The endogenous opioid system has generally been associated with regulation of pain. Endogenous opioid system also modulates the experience of distress and play a central role in many psychiatric and neurodevelopmental disorders. Decades of preclinical research on the analgesic effects of endogenous opioids, like, endorphins, suggests that opioid receptors have inhibitory-excitatory properties.

An exploratory study using a cold pressor-induced pain paradigm, found evidence that a combination of a nutraceutical agent that enhances endorphin release with one that switches opioid receptors from an excitatory to inhibitory mode not only increased pain tolerance, but also reduced emotional and physical distress. This discovery led to clinical application of a critically formulated endorphinergic treatment in 203 case studies over a two-year period.

Findings revealed the remarkable clinical efficacy and safety of this treatment in the relief of chronic emotional and physical distress, including anxiety, anger, depression, cravings, and hyperalgesia, as well as enhancement of well-being, productivity, mental clarity, relationships, and an adaptive response to life’s stresses. The study provides new insights into the role of endogenous opioid system imbalances in the development, treatment, and prevention of dysfunctional emotional and physical distress.

It is postulated that an Endorphinergic Distress Syndrome consists of abnormal endorphin levels together with opioid receptors predominately in their excitatory mode. Endorphinergic Distress Syndrome account for many core distress symptoms associated with chronic anxiety, addictions, pain, as well as affective personality, autism spectrum, attention-deficit, and distress-related medical problems.

The research has led to new endorphinergic formulations, combining Endorphin Enhancers, such as caffeine, with Opioid Receptor Switchers, such as n-acetylcysteine, for the relief of emotional and physical distress. The study provides a novel method to reverse the anxiogenic effects of caffeine and related hyper-excitatory substances.


What Stress Do To Our Body




To our forefathers, stress was an essential component of survival. That burst of adrenaline brought on by an encounter with a saber-tooth tiger gave them the speed to flee or the strength to kill the monstrous beast. Today’s challenges might not include facing hungry carnivores, but office politics, news, and dodging minibus taxis make for an equally stressful life, only now, running away is not an option.

Initially, feeling stressed is a positive response that enables us to complete tasks quickly and efficiently. Over time, stress build-up takes its toll on our bodies, usually on those areas that are genetically weak, and can lead to chronic illness. Most, if not all, diseases have their foundations in prolonged and ill-managed stress. This, together with a predisposing genetic defect that determines the weak link in the body, will, for example, lead to cardiovascular disease, cancer, slower recovery after operations and infections, arthritis, diabetes, obesity, asthma, eczema and many other disorders.

Because there are so many different manifestations of stress build-up, stress is often not recognized as the cause of illness. Worse still, once identified, many ignore it, fearing it is a sign of weakness. Stress can be an ever increasing out of control spiral. When we do not remove stress hormones through deliberate relaxation or by using the fight or flight response, our brain takes that to mean that we are not sufficiently prepared for fight of flight. Survival demands that our autonomic system comes to the rescue by pumping more and more stress hormones into our system, until we show signs of fight or flight or deliberate relaxation.

When we are first stressed, the brain signals the release of adrenalin and cortisol. These are hormones that boost our blood sugar and oxygen levels, push more blood to the brain, the result is increased alertness. The average adrenalin rush experienced while in traffic supplies enough glucose to keep one running for a mile. In the short term, stress suppresses the immune system, increasing the risk of infections; slows down the body’s rate of repair; slows down the metabolism; robs the body of vital nutrients. The symptoms can be recurrent headaches, vague aches and pains, dizziness, heartburn, muscle tension, dry mouth, excessive perspiration, pounding heart, insomnia and fatigue.

As we become more and more stressed out, our body begins to adapt to the high level of stress hormones. As a result, we feel increasingly anxious, fatigued and prone to mood swings. Long-term stress promotes rapid ageing, leads to weight gain, and increases the risk of developing osteoporosis, high blood pressure, heart disease, cancer and digestive problems. When we find ourselves stuck in the stress response and it is chronic, we become exhausted and depleted of vitamins and minerals. Our energy plummets, and our body’s ability to produce adrenalin decreases. Consequently, our emotions take a dive and we experience anxiety, fear, restlessness, irritability, anger, depression and insecurity, loss of libido, impaired memory and concentration.

We can recover by going with the fight or flight response. Physical exercise 5 times a week will act as the flight or fight response by using the body’s preparation for fight or flight and thereby lowering stress hormones to manageable levels. Regular, deliberate relaxation techniques used to lower or remove stress hormone build up from our systems such a floatation therapy; massage and meditation allow the body to naturally remove stress hormones from the body.

Many headaches are caused by stress. Tension headaches feel like a band tightening around the head. Relaxation, just like tension is a learned response. With regular practice, you can teach your body to relax, and learn what it feels like to be relaxed. The weightless environment of the floatation tank means that you do not have to support your body against gravity. Deep physical and mental relaxation follows.

In Mind-Body Medicine, there is a clear relationship between lower-back pain and stress. Again, relaxation techniques are the answer. In the floatation therapy, you are able to take quality time out, and reach deep relaxation very quickly and without years of training or practice. With regular massage, both the mind and body relaxes. To combat insomnia, breathe deeply and relax your body starting with your toes and working your way up to the top of your head. Take calcium and magnesium supplements before going to bed, and avoid caffeine as much as possible.

The body’s release of adrenaline during stressful events raises the heart rate and blood pressure. Adrenaline also stimulates a release of fat from the fat cells into the blood stream to supply energy for the fight or flight response. If unused, this fat is deposited on inside of the arteries. The New England Journal of Medicine published a study that indicates that surges of blood pressure can trigger heart attacks in susceptible people. Repeated elevations of blood pressure over periods of weeks and months accelerate atherosclerosis thereby increasing the risk of heart attacks.

Arthritis is often aggravated by stress. Learning to manage stress can help to relieve pain. Endorphins are the body’s natural pain killer. Massage helps to release the muscles that are tightening up around the body in response to pain, and encourage us to feel good about our bodies again. Sore muscles and pain occur when the muscles contract in response to stressful events, increasing the production of lactic acid and leading to pain. If you are able to deeply relax your muscles with the Epson salts in the water, the body is rid of lactic acid in the muscles, while the endorphins released by the brain help with pain relief.

In a stressful situation, digestive system slows down, freeing body’s energy for fight or flight. The stomach however continues to excrete acid, and ulcers may develop. Using relaxation techniques goes a long way in preventing the onset of stress-related illnesses. High levels of stress hormones dampen the functioning of the autoimmune system, leaving one more likely to catch whatever is floating around.

Blood moves from the intestines, when the body turns its focus to survival instead of healthy day-to-day functioning. This results in digestive problems for stressed individuals. The sudden de-stimulation of large areas of the nervous system triggers a spontaneous chain-reaction throughout the body to remove stress and leave one feeling wonderful and changed in body chemistry. Blood testing indicates that floating therapy reduce the level of stress and stress-related neurochemicals such as adrenaline, cortisol, and adrenocorticotropic hormone. It is high levels of these chemicals in the blood stream that leave one feeling stressed out. It is also because of these chemicals that stress is bad for health, causing heart disease and hampering function of immune system. Increasing levels of endorphins helps to relieve pain, and improve mood.

Exercise Have an Effect on Body in Countless Ways




Whether we exercise to lose weight, to reach a fitness goal or just for fun, exercise changes us. There is the red face and the sweating, the pounding heart and pumping lungs, the boost to our alertness and mood. We all know that staying physically active is essential to a long, healthy, productive life. We don’t often understand exactly what is happening behind the scenes.

Let us go through from head to toe and see what happens in the body when we exercise. The body calls on glucose; sugar the body has stored away from the foods we eat in the form of glycogen, for the energy required to contract muscles and spur movement. It also uses adenosine triphosphate, but the body only has small stores of both glucose and adenosine triphosphate. After quickly using up these supplies, the body requires extra oxygen to create more adenosine triphosphate. More blood is pumped to the exercising muscles to deliver that additional oxygen. Without enough oxygen, lactic acid will form instead. Lactic acid is typically flushed from the body within 30 to 60 minutes after finishing up a workout. Tiny tears form in the muscles that help them grow bigger and stronger as they heal. Soreness only means there are changes occurring in those muscles and this typically lasts a couple of days.

Our body needs up to 15 times more oxygen when we exercise, so we start to breathe faster and heavier. Our breathing rate will increase until the muscles surrounding the lungs just can’t move any faster. This maximum capacity of oxygen use is called VO2 max, which is the maximum capacity of an individual’s body to transport and use oxygen during incremental exercise, which reflects the physical fitness of the individual. The higher the VO2 max, the more fit a person is.

Like any muscle, the diaphragm can grow tired with all that heavy breathing. Some argue that as the diaphragm fatigues, it can spasm, causing a dreaded side stitch. Others argue a side stitch is due to spasms of the ligaments around the diaphragm instead, while others believe the spasms to originate in the nerves that run from the upper back to the abdomen and are caused by poor posture. Deep breathing and stretching can alleviate the discomfort in the middle of a workout, and preemptive strengthening in the gym can ward off future issues.

When we exercise, heart rate increases to circulate more oxygen via the blood at a quicker pace. The more we exercise, the more efficient the heart becomes at this process, so we can work out harder and longer. Eventually, this lowers resting heart rate in fit people. Exercise also stimulates the growth of new blood vessels, causing blood pressure to decrease in fit people. Because the body is pumping more blood to the muscles, it takes some away from the systems and functions that are not top priority at the moment, like digestion. This can result in tummy troubles. Movement, absorption and secretion in the stomach and intestines can all be affected.

Increased blood flow benefits the brain. Immediately, the brain cells will start functioning at a higher level, making us feel more alert and awake during exercise and more focused afterwards.

When we work out regularly, the brain gets used to this frequent surge of blood and adapts by turning certain genes on or off. Many of these changes boost brain cell function and protect from diseases such as Alzheimer’s, Parkinson’s or even stroke, and ward off age-related decline. Exercise triggers a surge of chemical messengers in the brain called neurotransmitters, which include endorphins, often cited as the cause of the runner’s high. The brain releases dopamine and glutamate, too, to get those arms and legs moving, as well as gamma-aminobutyric acid, a prohibitive neurotransmitter that actually slows things down, to keep us moving in a smooth and controlled manner. We will feel better, thanks to a bump in serotonin; a neurotransmitter well known for its role in mood and depression.

Hippocampus part of the brain is highly involved in learning and memory, and it is one of the only sections of the brain that can make new brain cells. Exercise facilitates this, thanks to the extra oxygen in the brain. Even when we stop exercising, those new brain cells survive, whereas many other changes in the brain during exercise eventually return to their normal state should we become less active.

The hypothalamus is responsible for body temperature, as well as salt and water balance, among other duties. As our body heats up, it tells the skin to produce sweat to keep us cool. This control center in the brain alerts the adrenal glands to pump out the hormones necessary for movement. It also releases growth hormones. As the body searches for more fuel to burn after using up the glycogen stores, it will turn to either muscle or fat. Human growth hormone acts as a security guard for muscle, telling the body to burn fat for energy instead.

The rate at which the kidneys filter blood can change depending on the level of exertion. After intense exercise, the kidneys allow greater levels of protein to be filtered into the urine. They also trigger better water reabsorption, resulting in less urine, in what is likely an attempt to help keep us as hydrated as possible.

A number of the so-called "stress" hormones released by adrenal glands are actually crucial to exercise. Cortisol, for example, helps the body mobilize its energy stores into fuel and adrenaline helps the heart beat faster so it can more quickly deliver blood around the body. As we pick up the pace, the body, like any engine, produces heat and needs to cool off. The blood vessels in the skin dilate, increasing blood flow to the skin. The heat then dissipates through the skin into the air.

At the hypothalamus’s signal, one of two types of sweat glands, the eccrine glands, get to work. These sweat glands produce odorless perspiration, a mixture of water, salt and small amounts of other electrolytes, directly onto the skin’s surface and when the sweat evaporates into the air, our body temperature drops. The second type of sweat gland is found predominantly in hair-covered areas, like the scalp, armpits and groin. These sweat glands produce a fattier sweat, typically in response to emotional stress that can result in odor when bacteria on the skin begin to break it down. The capillaries close to the skin’s surface in the face dilate as well, as they strain to release heat. For some exercisers, this may result in a particularly red face after a workout.

Exercising puts extra weight on the joints, sometimes up to five or six times more than our bodyweight. Ankles, knees, hips, elbows and shoulders all have very different functions, but operate in similar ways. Each joint is lined with cushioning tissue at the ends of the bones called cartilage, as well as soft tissue and lubricating fluid, to help promote smooth and easy motion. Ligaments and tendons provide stability. Over time, the cushioning around the joints can begin to wear away or degenerate, as happens in people with osteoarthritis, the most common type of arthritis.


Just Get Up, Get Out, and Put One Foot In Front Of the Other


The modern world we live in is full of stress, unhappiness, insecurity, and depression. Our jobs, the commutes, traffic, finances, family, relationships, dating, the news, and never enough time all weigh heavily on us, dragging us down. Stress wears the body out and depletes important neurotransmitters, nutrients, and minerals which lead to fatigue, irritability, depression, anxiety, inability to sleep, bad eating habits, and many other negative effects.

The cure to mental health problems and many physical problems is as simple as taking a 30-minute walk each day. Exercise decreases stress, relieves anxiety, creates a sense of well-being, increases confidence, improves sleep, and relaxes both body and mind. This is in addition to the benefits to heart health, circulation, the lungs, and our muscles.

How many of us watch a half hour of television each night? Just cutting out one short show each day gives you plenty of free time to take a walk. If you have a treadmill, you can even keep the show and walk at the same time. We aren’t talking about running a marathon or even jogging a mile. You don’t have to push yourself too hard; just get up, get out, and put one foot in front of the other for 30 minutes. Walking is one of the easiest forms of exercise. You can do it anywhere, even in place if you can’t get outside. If half an hour leaves you gasping for air, start with 20 minutes and work up to 30 over a few weeks. After 30 minutes of any exercise, the muscles run out of stored oxygen and turn to anaerobic respiration. This builds up lactic acid which signals the brain to release endorphins. Endorphins reduce pain and stress while creating sensations of pleasure and euphoria. Endorphins act much like antidepressants, but without the side effects, synthetic drugs, and addictive properties.

Exercise improves memory and cognitive functions by increasing the connections between neurons. This makes it easier to deal with stress as brain moves faster, work is easier, and it takes less effort to pull up memories. Thirty minutes a day is also the perfect amount to prevent weight gain and to safely, slowly lose pounds. Walking lowers bad cholesterol, raise good cholesterol, lower blood pressure, reduce the risk of diabetes, build lean muscles, and strengthen bones. Once you’re comfortable with 30 minutes a day, feel free to extend it to 45 minutes or even an hour. The time is well spent when it adds years to your life and makes those years healthier, happier, and more thought through. Make it a habit and it will be one of the best habits you’ve ever picked up. It is difficult at first, but you’ll be glad in the long run as you feel happier, less stressed, more confident, and healthier.


It All Happens For A Reason


It is a fact that we don’t see all there is before us, our eyes ability is limited to see this dimension only, our brains filter out other information that it deems is unnecessary. What we conceive as reality in our minds may all be an illusion created by our mind, thus becoming the greatest lie of all. It is true that we alone are the sole architect who can create and form our reality. Are you really sure that a floor can’t also be a ceiling? The human understanding is like a false mirror, which, receiving rays irregularly; distorts and discolors the nature of things by mingling its own nature with it.

Imagination is all an illusion, a vision of what was, is, could be, a conception of a thought brought into reality by the wandering of an ever restless mind. Illusions commend themselves to us because they save us pain and allow us to enjoy pleasure instead. We must therefore accept it without complaint when they sometimes collide with a bit of reality against which they are dashed to pieces. Imagination is the one weapon in the war against reality.

As you perceive reality When you argue with reality you are going to loose. I’m not crazy about reality, but it’s still the only place to get a decent meal. Reality does not conform to the ideal, but confirms it. Reality leaves a lot to the imagination. Reality is that which, when you stop believing in it, doesn’t go away. Until we realize that things might not be we cannot realize that things are. Since we cannot change reality, let us change the eyes which see reality.

Your goals, minus your doubts, equal your reality. People see the world not as it is, but as they are. Reality is not always probable, or likely. Don’t dwell on reality; it will only keep you from greatness. Reality bites… and doesn’t let go. One might speak to great length of the three corners of reality what was seen, what was thought to be seen, and what was thought ought to be seen. Time and memory are true artists; they remold reality nearer to the heart’s desire. There are some people, who live in a dream world, and there are some who face reality; and then there are those who turn one into the other. Whatever we plant in our subconscious mind and nourish with repetition and emotion will one day become a reality.

The reality of life is that your perceptions — right or wrong — influence everything else you do. When you get a proper perspective of your perceptions, you may be surprised how many other things fall into place. There are intangible realities which float near us, formless and without words; realities which no one has thought out, and which are excluded for lack of interpreters. It takes only one other person to say it’s so-one other point of reality to make something real.


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