Archive for the ‘Medicine’ Category

Hypertension Essentials

Hypertension is a major risk factor for stroke, myocardial infarction, vascular disease, and chronic kidney disease. Prehypertension, significantly increases stroke risk. It is reported that, after adjustment for multiple cardiovascular risk factors, pre-hypertension which is blood pressure range 120 to 139/80 to 89 millimeter of Mercury is associated with increased risk for stroke, compared with an optimal blood pressure. Patients in the high range of pre-hypertension, that is to say, 130 to 139/85 to 89 millimeter of Mercury have 95% increased risk of stroke, compared with 44% increased risk for those in the low range of prehypertension, which is 120 to 129/80 to 84 millimeter of Mercury.

Hypertension is defined as a systolic blood pressure of 140 millimeter of Mercury or more, or a diastolic blood pressure of 90 millimeter of Mercury or more, or taking antihypertensive medication. Based on recommendations of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, the classification of blood pressure for adults aged 18 years or older has been as follows: Normal blood pressure with systolic lower than 120 millimeter of Mercury and diastolic lower than 80 millimeter of Mercury. The Pre-Hypertensive patients are those who are with systolic of 120 to 139 millimeter of Mercury and diastolic of 80 to 89 millimeter of Mercury. Stage 1 hypertensive patients have the systolics ranging 140 to 159 millimeter of Mercury and diastolic anywhere between 90 to 99 millimeter of Mercury. Stage 2 hypertension is diagnosed when systolics are consistently in the 160 or greater range and diastolic of 100 millimeter of Mercury or greater.

Hypertension may be primary, which may develop as a result of environmental or genetic causes, or secondary, which has multiple etiologies, including renal, vascular, and endocrine causes. Primary or essential hypertension accounts for 90-95% of adult cases, and secondary hypertension accounts for 2-10% of cases.

The evaluation of hypertension involves, accurately measuring the patient’s blood pressure, taking a focused medical history, performing a thorough physical examination, and obtaining results of routine laboratory studies. A 12-lead electrocardiogram should also be obtained. These measures help determine the presence of end-organ disease, possible causes of hypertension, cardiovascular risk factors, and as well gives baseline values for judging biochemical effects of therapy. Other studies may be obtained on the basis of clinical findings or in individuals with suspected secondary hypertension and/or evidence of target-organ disease, such as complete blood count, chest radiograph, uric acid, and urine microalbumin.

Guidelines from JNC, the American Diabetes Association and the American Heart Association/American Stroke Association recommend lifestyle modification as the first step in managing hypertension.

JNC’s recommendations to lower blood pressure and decrease cardiovascular disease risks include 2 or more lifestyle modifications are combined. Weight Loss leads to dropping of systolic blood pressure by 5-20 millimeter of Mercury per 10 kg. Limiting alcohol intake to no more than 30 mL of ethanol per day for men and 15 mL of ethanol per day for women helps the blood pressure to drop by 2-4 millimeter of Mercury. Reducing Sodium Intake to no more than 2.4 grams of sodium or 6 grams of sodium chloride leads to reduction of 2-8 millimeter of Mercury. Maintaining adequate Intake of Dietary Potassium, approximately 90 millimoles per day and adequate Dietary Calcium & Magnesium are some of the other lifestyle modifications advocated by JNC. Smoking cessation and reducing intake of Dietary Saturated Fat & Cholesterol is good for overall cardiovascular health. Engaging in Aerobic Exercise for at least 30 minutes daily for most days reduces the systolic blood pressure by 4-9 millimeter of Mercury.

The American Heart Association/American Stroke Association recommends a diet that is low in sodium, high in potassium along with consumption of fruits, vegetables, and low-fat dairy products to reduce blood pressure and lower the risk of stroke.

The 2013 European Society of Hypertension and the European Society of Cardiology guidelines recommend a low-sodium diet consisting of 5 to 6 grams per day as well as reducing body-mass index to 25 kg per meter square and waist circumference to less than 102 cm in men and 88 cm in women.

If lifestyle modifications are insufficient to achieve the goal blood pressure, there are several drug options for treating and managing hypertension. Thiazide diuretics are the preferred agents in the absence of compelling indications. Compelling indications may include high-risk conditions such as heart failure, ischemic heart disease, chronic kidney disease, and recurrent stroke, or those conditions commonly associated with hypertension, including diabetes and high coronary disease risk. Drug intolerability or contraindications may also be factors. Use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, and beta-blockers are all acceptable alternative agents in such compelling cases.

Posted May 2, 2014 by dranilj1 in Medicine

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Women Are More Complex—Genetically



There are things that I will never understand like misogyny, rape, and abuse. I am a straight dominant man. I cannot look at a woman and not be amazed at the beauty of her form, the strength of her mind, and the mysteries within her eyes. There is a beauty in every woman and only the right man brings it shining out. If a woman is not interested in you, she is not a slut or bitch; she is simply not for you. A confident man with nothing to prove merely wishes her a goodnight, tells her that she is still beautiful in his eyes and goes on his way to look for the right one for him. If you are a straight male and you don’t love and respect a woman, the problem is not with them, it is with you. Respect is never weak. Respect amplifies everything that is inside. So, good becomes great. Bad becomes worse, a strong man, who has known power all his life, will lose respect for that power. But a weak man knows the value of strength, and knows compassion. Women are genetically more complex because the active X chromosome is a mix of mom’s and dad’s. Men’s X chromosome all comes from mom and their Y chromosome carries less than 100 genes, compared with about 1,500 for the X chromosome.

Although women may not be scientifically proven to differ from men in intelligence or motivation, researchers have discovered women are more complex—genetically, at least. In a study published in Nature, researchers from Duke and Pennsylvania State University found surprising levels of genetic variation on the X chromosome—an area that has not been fully explored until now. The findings suggest women and men are more different than originally believed. When considering this additional number of genes as well as the variability in gene expression on the X chromosome, women are more complex than men, in that sense.

The human genome, the complete set of genes within an individual, is comprised of 23 pairs of chromosomes, one pair of which is responsible for determining gender. These two chromosomes, called sex chromosomes, are designated by the letters X and Y. Males have a combination of X and Y, while females have two X chromosomes. Genes, a DNA sequence that encodes the recipe to create proteins in the body, are located on chromosomes. Because women have two sets of X genes, female cells choose to de-activate one copy of the X chromosome in a process called “silencing.” This is to avoid any harmful effects that would result in double expression of such genes.

At least 15 percent of the genes on the X chromosome escape silencing and another 10 percent show variable degrees of expression among women. The results of the study, however, not only revealed the degree of genetic differences between the sexes, they also showed differences among women themselves. While one woman may have her copy of a particular X-linked gene expressed, another woman may not. These un-silenced or partially silenced genes on the X chromosome comprise more than 1 percent of the entire genome, accounting for more than 200 to 300 more expressed genes in women than in men. What the finding superimposes upon the characteristic differences between men and women is how much of that variation is present from one female to another.

Recognizing this variation is important for medicine, as there are a large number of diseases that are much more common among women than men. A lot of the differences in gender-based medicine are due to hormonal effects and cultural effects. We should look in addition at the genetic differences between men and women. There are still many basic questions to be answered, such as whether this variability in silencing is affected by age or is present in different tissues. The ultimate goal is to provide information to help identify patients who have the highest risks for sex-associated diseases and guide treatment. These diseases, which range from heart disease to psychiatric disorders, involve numerous genes that are found on other chromosomes in addition to the X.

Researchers went into this from a very basic perspective to understand the basis of silencing events, but now they are finding very important results that have medical implications such as genetic counseling for hereditary diseases. In the case of Turner’s syndrome, in which only one of the two X chromosomes is functional in a female, deficits in the genes responsible for the symptoms can now be clarified, providing scientists with a better understanding of the biology underlying the genetic disease. We can never answer all the questions; we can just ask better questions.


 

How to Handle Belch?


Belching is the act of bringing up air from the stomach. It produces a characteristic sound. Belching is most often a normal process. The purpose of belching is to release air from the stomach. Every time you swallow, you also swallow air, along with fluid or food. As the air builds up in the upper stomach, it causes stretching of the stomach that triggers the lower esophageal sphincter muscle to relax. This lets air escape up the esophagus and out the mouth. Excessive or repeated belching may be caused by unconsciously swallowing air what is medically called aerophagia. Depending on the cause, belching may change in duration and intensity. Symptoms such as nausea, dyspepsia, and heartburn may be relieved by belching.

Belching is caused by the pressure caused by the unconscious swallowing of air and or gastroesophageal reflux disease.

One could get relief by lying on side or in a knee-to-chest position until the gas passes. Avoid chewing gum, eating quickly, and eating gas-producing foods and beverages. If one has gastroesophageal reflux disease; learning to manage the symptoms of gastroesophageal reflux disease will alleviates belch. Belching is usually a minor symptom. However, calling a health care provider is warranted if the belching does not go away, or if one also has other symptoms.

The health care provider will examine and ask questions about medical history and symptoms, including but not limited to whether it is the first time this has occurred? Is there a pattern to belching? For example, does it happen when one is nervous or after one has been consuming certain foods or drinks? What other symptoms does one have? The Diagnostic tests depend on the findings of the physical examination, and other signs or symptoms one has with the belching.

Other alternative names for belching include burping, eructation or gas.

Imaging No Help in Gallbladder Surgery Risk



In an analysis of a procedure used to help prevent common duct injury during gallbladder removal surgery, use of radiologic examination of the ducts during gallbladder surgery was not associated with a reduced risk of common duct injury, according to a study in the August 28 issue of JAMA.

Biliary anatomy misidentification during gallbladder removal can result in injury to the common hepatic duct or common bile duct. Common duct injuries cause significant short and long-term morbidity including major operations, multiple hospitalizations, and biliary strictures. Elimination of common duct injury is desirable, but it has remained stubbornly present with rates ranging from 0.3 percent to 0.5 percent, according to information. When routinely used, intra-operative cholangiography is thought to prevent common duct injury. However, controversy exists regarding the effectiveness of routine use in the prevention of common duct injury.

Kristin M. Sheffield, Ph.D., and Taylor S. Riall, M.D., Ph.D., of the University of Texas Medical Branch, Galveston, and colleagues investigated the association between intraoperative cholangiography use during cholecystectomy and common duct injury, using instrumental variable analysis, an effective way to overcome unmeasured confounding, that is to say, factors influencing outcomes not found in the database. The researchers identified Medicare beneficiaries from Texas Medicare claims data who underwent inpatient or outpatient cholecystectomy for conditions including biliary colic or biliary dyskinesia, acute cholecystitis, or chronic cholecystitis. The percentage of intraoperative cholangiography use at the hospital and by surgeon was the instrumental variables. Patients with claims for common duct repair operations within 1 year of cholecystectomy were considered as having major common duct injury.

In a logistic regression model controlling for patient, surgeon, and hospital characteristics, the odds of common duct injury for cholecystectomies performed without intraoperative cholangiography were increased compared with those performed with it. When confounding was controlled with instrumental variable analysis, the association between cholecystectomy performed without intraoperative cholangiography and duct injury was no longer significant.

Significant controversy exists regarding the role of intraoperative cholangiography in the prevention of common duct injury during cholecystectomy. Previous population-based studies using data from Medicare claims, hospital discharge records, and national inpatient registries report nearly 2-fold higher rates of injury in cholecystectomies performed without intraoperative cholangiography. In the present study using Texas Medicare claims data, the association between intraoperative cholangiography and common duct injury was highly sensitive to the analytic method used.

Failure to account for potentially confounding variables not routinely captured in administrative databases has a major effect on the interpretation of the findings. Intraoperative cholangiography was not associated with significant reduction in common duct injury using instrumental variable analysis. Instrumental variable analysis balances unmeasured confounding variables to better align risk factors in comparator groups. With better control for unmeasured confounding variables, intraoperative cholangiography was no longer associated with common duct injury. Based on these results, routine intraoperative cholangiography should not be advocated as means for preventing common duct injury.

While this report does not definitively close the door on routine intraoperative cholangiography use, use of directed attention to an important clinical debate by using a new approach to revisit the outcomes of intraoperative cholangiography using observational data. While the true effect of intraoperative cholangiography on the safety of laparoscopic cholecystectomy remains controversial, this study undoubtedly reinvigorates the discussion.


Fascinating Story of Getting Energy from Food We Eat!


The proteins, lipids, and polysaccharides that make up most of the food we eat must be broken down into smaller molecules before our cells can use them either as a source of energy or as building blocks for other molecules. The breakdown processes must act on food taken in from outside, but not on the macromolecules inside our own cells. The enzymatic breakdown of food molecules is therefore digestion, which occurs either in our intestine outside cells, or in a specialized organelle within cells; the lysosome. A membrane that surrounds the lysosome keeps its digestive enzymes separated from the cytosol. In either case, the large polymeric molecules in food are broken down during digestion into their monomer subunits—proteins into amino acids, polysaccharides into sugars, and fats into fatty acids and glycerol through the action of enzymes. After digestion, the small organic molecules derived from food enter the cytosol of the cell, where their gradual oxidation begins. Oxidation occurs in two further stages of cellular catabolism. Stage 2 starts in the cytosol and ends in the major energy-converting organelle, the mitochondrion; stage 3 is entirely confined to the mitochondrion.

In stage 2 a chain of reactions called glycolysis converts each molecule of glucose into two smaller molecules of pyruvate. Sugars other than glucose are similarly converted to pyruvate after their conversion to one of the sugar intermediates in this glycolytic pathway. During pyruvate formation, two types of activated carrier molecules are produced; adenosine-5′-triphosphate and nicotinamide adenine dinucleotide. The pyruvate then passes from the cytosol into mitochondria. There, each pyruvate molecule is converted into carbon dioxide plus a two-carbon acetyl group; which becomes attached to coenzyme A, forming acetyl coenzyme A, another activated carrier molecule. Large amounts of acetyl coenzyme A are also produced by the stepwise breakdown and oxidation of fatty acids derived from fats, which are carried in the bloodstream, imported into cells as fatty acids, and then moved into mitochondria for acetyl coenzyme A production.

Stage 3 of the oxidative breakdown of food molecules takes place entirely in mitochondria. The acetyl group in acetyl coenzyme A is linked to coenzyme A through a high-energy linkage, and it is therefore easily transferable to other molecules. After its transfer to the four-carbon molecule oxaloacetate, the acetyl group enters a series of reactions called the citric acid cycle. The acetyl group is oxidized to carbon dioxide in these reactions, and large amounts of the electron carrier nicotinamide adenine dinucleotide are generated. Finally, the high-energy electrons from nicotinamide adenine dinucleotide are passed along an electron-transport chain within the mitochondrial inner membrane, where the energy released by their transfer is used to drive a process that produces adenosine-5′-triphosphate and consumes molecular oxygen. It is in these final steps that most of the energy released by oxidation is harnessed to produce most of the cell’s adenosine-5′-triphosphate.

Because the energy to drive adenosine-5′-triphosphate synthesis in mitochondria ultimately derives from the oxidative breakdown of food molecules, the phosphorylation of adenosine diphosphate to form adenosine-5′-triphosphate that is driven by electron transport in the mitochondrion is known as oxidative phosphorylation. Fascinating events occur within the mitochondrial inner membrane during oxidative phosphorylation. Through the production of adenosine-5′-triphosphate, the energy derived from the breakdown of sugars and fats is redistributed as packets of chemical energy in a form convenient for use elsewhere in the cell. Roughly, 109 molecules of adenosine-5′-triphosphate are in solution in a typical cell at any instant, and in many cells, all this adenosine-5′-triphosphate is turned over, that is, used up and replaced every 1–2 minutes.

In all, nearly half of the energy that could in theory be derived from the oxidation of glucose or fatty acids to water and carbon dioxide is captured and used to drive the energetically unfavorable reaction orthophosphate plus adenosine diphosphate giving adenosine-5′-triphosphate. By contrast, a typical combustion engine, such as a car engine, can convert no more than 20% of the available energy in its fuel into useful work. The rest of the energy is released by the cell as heat, making our bodies warm.


Getting an Hour More of Sleep Per Night May Help Obese Adolescents Shed Pounds



Reduced sleep is linked with increase in body mass index in adolescents aged 14-18 years, particularly in heavier adolescents, according to a new study. Those who sleep an extra hour or more a night could lower their body mass index and so prevent overweight and obesity.

Physical inactivity and increased caloric intake explains the connection between short sleep and adolescent obesity. Short sleepers could be more exhausted during the daytime and spend less time being physically active. It is possible that short sleep add to total caloric intake due to more eating opportunities.

Short sleep affects hormones that regulate appetite and energy homeostasis. Such hormonal changes explain why there is an association between short sleep and adolescent obesity. An extra hour of sleep is associated with only a slight reduction in BMI at the 10th percentile. In comparison, greater reductions in BMI are observed at the 50th and 90th percentiles.

Increasing sleep from 8 to 10 hours per day at age 18 years result in a 4% reduction in the number of adolescents with a BMI higher than 25 kilograms per meter squared. The relationship between disturbed circadian rhythms and weight gain is well documented in animal models. However, it is not known if these findings in animals translate to humans, and thus more research is desirable to determine if staying awake at night and eating at night is associated with adolescent obesity.

Primary care physicians should advise adolescent patients to adopt good sleep hygiene practices, such as establish routine bed and wake times each day, associate the bedroom with sleep and not television viewing, and increase physical activity during the daytime.

Primary care physicians and other health care professionals could lend their support to changes in policies that would help support longer sleep duration among adolescents, for example, later high school start times and more physical education classes to increase daytime physical activity.

Achieving sufficient sleep needs should center on healthier eating, being more physically active, and creditability to the significance of sufficient sleep duration.

Credits: Dr Mitchell.

DNA Mapping Could Save Your Life


You may think you know yourself like the back of your hand, but unless you’ve been DNA tested, there’s probably a lot you don’t know about yourself. Within each of the 50 trillion cells in your body rests the microscopic DNA that programs your entire being; your hair color, your height, your freckles or lack thereof, your likelihood of developing cancer and whether or not you can taste cilantro. Nevertheless, few people in their lifetime have actually unlocked this information via DNA mapping. For starters, it used to be quite expensive. Some might not even realize they have access to this information, while others simply might want to know what their DNA has in store for them as life unfolds.

Crushing these barriers is Anne Wojcicki’s 23andMe, a $99 DNA testing kit that requires just a few milliliters of spit. That’s it, no blood tests or pesky skin pricks. Eight weeks after mailing the kit back, you’ll receive a full genetic report that outlines your health risks and ancestry. During those two months, the scientists in 23andMe’s lab extract DNA from the cells in your spit and amplify the DNA so they have enough to work with. From there, the DNA is genotyped, yielding your unique report of what makes you, you. To get the full picture of their ancestry, though, women need to have their father or brother take the test; while everyone has mitochondrial DNA, paternal DNA is passed along through the Y chromosome, which women don’t have.

Thus far, more than 200,000 users have been genotyped via 23andMe, and 90% of those have opted to participate in the company’s research efforts. Each survey question counts as a data point, and to date, 23andMe has collected more than 100 million data points, with 2 million more coming each week. The company’s in-house research has studied life-threatening sarcomas, Parkinson’s disease and diabetes, as well as lighter topics; unibrows and why Shar-Pei dogs are so wrinkly.

With an eye toward revolutionizing health care, the company raised 50 million dollars last year to drop the price of the kits from $999 to $99 and dramatically grow its database. In her blog post about the price drop, Wojcicki writes, "This change is not just about a new price point for personal genetic testing. It is about an ambitious plan that could transform medicine for generations to come."

Would you do the test, if it revealed that you have an increased risk for Parkinson’s disease or lung cancer? People have strong opinions either way, but knowledge is power. It is very holistic to empower people with their genetic information. You, the individual, don’t have a voice in the system. You’re talked about as a human subject, with no agency in the health care system. You’re simply told what you’re going to get, and it’s often dictated by your insurance company.

The industry is filled with really, really good people who want to make a difference in health care, but the system is set up in such a way that we really don’t have optimal health care. Take Type 2 Diabetes, for example. It’s a preventable disease, but no one makes money until you actually develop diabetes and need to buy insulin and testing strips. The system is set up so they make tons of money once you’re diabetic, but if you don’t develop diabetes, no one makes money. This is a fundamental flaw in the system.

Because your genotype outlines your risks for developing various diseases and disorders, health care could one day focus on prevention. Patients would rather prevent a disease than treat it effectively, but in today’s system, doctors are taught how to treat various conditions, not prevent them altogether. Public should be empowered with their genetic information. It is really important information about your health, really fascinating information about your ancestry, and the aggregate data of having millions and millions of people together will create this incredibly powerful database that’s going to filter back to you and give you more information about you and make you healthier.

Interestingly, health care reform has piqued insurance companies’ interest in prevention, because understanding your genetics could keep you healthier and prevent complications and costly side effects. But while insurance companies may want this information, it is firmly protected by federal law, and that the information in essence, your identity, should be controlled by the individual at this point in time.

Though 23andMe has been around since 2006, its growth and database have skyrocketed since the $99 price point was introduced. With more people in the database, the company can provide a fuller user experience and tell you more about what your genes mean. What company is really focused on is growth right now. As the customer base grows, so too do the volume of emotional stories. 23andMe saved many lives and having your genetic information will revolutionize things for you.

Wojcicki has a degree in biology from Yale, her father is a particle physicist, and she grew up on Stanford’s campus, going to particle physics meetings and listening to people who want to challenge Einstein’s theories. The particle physicist community is a really fabulous community, and they’re really about the pursuit of science for the sake of science and pursuit of truth. It’s not a commercial entity, and I have a huge respect for them because they’re really passionate about what they do.


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